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Science • 2026-04-16 23:49

Natural Hormone FGF21 Reverses Obesity in Mice by Boosting Energy Burn

Scientists have identified the hormone FGF21 as capable of reversing obesity in mice by activating a newly discovered brain circuit in the hindbrain — the same region targeted by GLP-1 drugs like Ozempic. Unlike those drugs, FGF21 works not by suppressing appetite but by increasing the body's energy expenditure. The findings could lead to more targeted treatments for obesity and liver disease.

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